RhoGEF-mediated vasoconstriction in hypertension

Enhanced alpha-adrenoreceptor-mediated vasoconstriction in essential hypertension.

Forearm blood flow (FAF) has been determined using venous occlusion plethysmography in 24 patients with essential hypertension (EHT) and in 16 age-matched normotensive subjects (NT) under basal resting conditions, following nonspecific vasodilatation with sodium nitroprusside and after intraarterial infusion of the postjunctional alpha-blocking drug, prazosin. Under basal conditions, FAF was si...

Enhanced hypoxic pulmonary vasoconstriction in hypertension.

In this study, we tested the hypothesis that hypoxic pulmonary vasoconstriction may be enhanced in systemic hypertension. The hypothesis took origin from the following two considerations: alveolar hypoxia constricts the pulmonary vessels by enhancing the Ca2+ penetration across sarcolemma of the smooth muscle cells and systemic high blood pressure is associated with an elevation of tone and rea...

Vasoconstriction and remodeling in pulmonary hypertension.

In one group of sheep, Escherichia coli endotoxin was given intravenously three times per week for ten weeks, and in another group the cyclooxygenase inhibitor indomethacin was given subcutaneously two times per day for three weeks. Both groups developed the structural and functional changes of modest but sustained pulmonary hypertension and showed granulocyte sequestration in the peripheral lu...

Vasoconstriction and medial hypertrophy in pulmonary hypertension.

Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.

Vascular remodeling, rather than vasoconstriction, is believed to account for high vascular resistance in severe pulmonary arterial hypertension (PAH). We have found previously that acute Rho kinase inhibition nearly normalizes PAH in chronically hypoxic rats that have no occlusive neointimal lesions. Here we examined whether Rho kinase-mediated vasoconstriction was also important in a rat mode...